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Does Ibogaine Actually Work?

Ibogaine, a naturally occurring psychoactive substance found in the root bark of the African shrub Tabernanthe iboga, has been gaining attention as a potential treatment for addiction. With numerous ibogaine treatment clinics emerging worldwide, many are curious about its efficacy and safety. This blog post delves into whether ibogaine actually works, examining scientific studies, anecdotal evidence, and expert opinions.

What is Ibogaine?

Ibogaine is an indole alkaloid that has been used for centuries in traditional African spiritual practices. In recent years, it has garnered interest for its purported ability to interrupt addiction cycles. Unlike conventional treatments that often require long-term medication or therapy, ibogaine is typically administered in a single session or a few sessions over a short period.

How Does Ibogaine Work?

Mechanism of Action

The exact mechanism by which ibogaine works is not fully understood. However, research suggests that it may interact with several neurotransmitter systems in the brain:

  • Dopamine System: Ibogaine appears to modulate dopamine levels, which are crucial in addiction pathways.
  • Serotonin System: It also affects serotonin receptors, potentially improving mood and reducing cravings.
  • NMDA Receptors: By interacting with NMDA receptors, ibogaine may help reset neural pathways associated with addictive behaviors.

Detoxification and Psychological Effects

Ibogaine is believed to facilitate detoxification by alleviating withdrawal symptoms and reducing cravings. Additionally, many users report profound psychological insights during their experience, which can be therapeutic.

Scientific Evidence

Clinical Studies

While there is growing anecdotal evidence supporting ibogaine’s efficacy, clinical research remains limited. Some studies have shown promising results:

  • A 2017 study published in the American Journal of Drug and Alcohol Abuse found that 50% of participants remained abstinent from opioids six months after receiving ibogaine treatment.
  • Another study conducted by MAPS (Multidisciplinary Association for Psychedelic Studies) reported significant reductions in opioid withdrawal symptoms and cravings among participants.

Limitations of Research

Despite these encouraging findings, it’s important to note the limitations:

  • Small Sample Sizes: Many studies have small sample sizes, making it difficult to generalize results.
  • Lack of Control Groups: Some studies lack control groups or use self-reported data, which can introduce bias.
  • Regulatory Hurdles: Legal restrictions on psychedelic research have hindered large-scale clinical trials.

Anecdotal Evidence

Many individuals who have undergone treatment at ibogaine treatment clinics report life-changing results. Testimonials often highlight rapid detoxification from substances like opioids and alcohol. Users frequently describe experiencing deep emotional healing and gaining insights into their addictive behaviors.

However, anecdotal evidence should be approached with caution. Personal experiences can vary widely, and what works for one person may not work for another.

Safety Concerns

Potential Risks

While some people experience positive outcomes with ibogaine treatment, it’s not without risks:

  • Cardiovascular Issues: Ibogaine can cause heart arrhythmias and other cardiovascular problems.
  • Psychological Distress: The intense psychological experience can be overwhelming for some individuals.
  • Lack of Regulation: Many ibogaine treatment clinics operate in countries with lax regulations, raising concerns about safety standards.

Mitigating Risks

To mitigate these risks:

  1. Medical Screening: Comprehensive medical screening before treatment can identify potential contraindications.
  2. Supervised Treatment: Treatment should be conducted under medical supervision to manage any adverse effects.
  3. Post-Treatment Support: Ongoing support after the initial treatment can help maintain sobriety and address any psychological issues that arise.


So does ibogaine actually work? The answer is nuanced. While there is promising evidence suggesting that ibogaine can be effective in treating addiction—particularly opioid dependence—more rigorous scientific research is needed to fully understand its efficacy and safety profile.

If you’re considering this form of therapy, it’s crucial to do thorough research and consult healthcare professionals experienced in addiction medicine. Ibogaine treatment clinics offer hope for many struggling with addiction but should be approached cautiously due to potential risks involved.

In summary:

  1. Ibogaine shows promise but lacks extensive clinical validation.
  2. Anecdotal evidence supports its effectiveness but varies widely.
  3. Safety concerns necessitate careful consideration and professional supervision.

As more research emerges and regulations evolve, we may gain clearer insights into whether ibogaine could become a mainstream option for treating addiction effectively and safely.

US government will test ibogaine as an addiction treatment

When one typically thinks of psychedelics, the word “trip” is top of mind. Ibogaine has proven effective at treating addiction to tobacco, alcohol, and drugs. Yet, for those naysayers that continue to doubt the treatment based on the fact a “trip” is part of the equation, Will Yakowicz delivers a fascinating story on professor David Olson and his pursuit of a “no-trip” treatment.

In addition to being a faculty member at the University of California at Davis, Olson is also the co-founder of Delix, a company attempting to remove the “trip” from psychedelics while still preserving their therapeutic components. The company’s Delix-7 is said to do just that with ibogaine.

Olson is partial to a theory that the psychedelic trip is not necessary to treat the common addictions that ibogaine treats. The most important part, according to Olson, is the development of neuroplasticity which helps the brain form new neural connections in a positive way.

More research is needed, but this is indeed a promising line of research.

Read the full article here:

Colorado psilocybin dmt ibogaine

Colorado now joins a handful of states in advancing mental health treatment with previously banned substances. Bill HB22-1116 would establish “a policy review panel to study plant-based medicines to support mental health.” As author Nick Wills details in, “Colorado bill would study these natural hallucinogens,” psilocybin, psilocyn, dimethyltrytamine, and igobaine would be the eligible plants should the bill become law. 

Colorado has a history with similar decriminalization. In 2019 mushrooms with psilocybin were decriminalized where much research has shown the positive affect psilocyn has on serotonin, a hormone that affects our digestion, sleep, and mood. Ibogaine has yielded exceptional results with those addicted to opioids. 

In terms of next steps, the legislation will be reviewed by the Public & Behavioral Health and Human Services Committee in February 2022.

Read full article here:

Psychedelic ibogaine addiction recovery opioid

Only 5 to 10 percent of those with an opioid addiction successfully quit via conventional methods. To put that into perspective, in a room with 100 folks, only 5 to 10 will eventually achieve sobriety. A stunning 90 to 95 will remain mired in their addiction.

There must be another route, thought Dimitri H. In a riveting Rolling Stone piece by Jonathan Reiss, we are introduced to Dimitri and his 20 plus years of heroin addiction. After experimenting with the typical treatments, Dimitri booked a trip to Greece to bid farewell to his ancestral homeland and take his own life. But a last-minute stop in the Netherlands and an experimental treatment with ibogaine literally changed everything.

Today Dimitri is helping to treat thousands of opioid addicts whom conventional treatments have failed. He is a self-proclaimed “wounded warrior,” and based on the Alcoholics Anonymous program Dimitri has created a new program that is having great success.

Read full article here: