Scientists Develop Synthetic Form of Ibogaine

University of California, Davis researchers have created a non-hallucinogenic version of ibogaine. The new substance could prove just as effective as the psychedelic original used to treat addiction and psychological illnesses such as depression and post-traumatic stress disorder.

David Olson, an assistant professor of chemistry at UC Davis, detailed the discovery in the December 2020 issue of Nature.   

In the study, a series of rodent experiments showed that mice decreased their alcohol consumption and experienced a delayed opiate relapse when given the non-hallucinogenic Tabernanthalog (TBG). The synthetic version is water-soluble and has fewer adverse effects than ibogaine. Olson says he’s optimistic that TBG can treat addiction and many illnesses related to addiction, such as depression and anxiety.

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